/* ==========================================================================
   EthopeBio — design tokens
   ========================================================================== */

:root{
  --bg: #F5FAF8;
  --surface: #FFFFFF;
  --surface-dim: #EDF4F1;
  --line: #DAE7E2;

  --ink: #0E2622;
  --ink-soft: #4C6864;
  --ink-faint: #86A29C;

  --teal: #0E9C8F;
  --teal-deep: #076A61;
  --teal-tint: #E3F5F2;

  --coral: #FF6B4A;
  --coral-deep: #E14E30;

  --lobe-frontal: #FF6B4A;
  --lobe-parietal: #0E9C8F;
  --lobe-temporal: #7B6EF6;
  --lobe-occipital: #F2B705;
  --lobe-cerebellum: #33A6D8;
  --lobe-stem: #E8558A;
  --lobe-limbic: #4CAF6D;

  --font-display: Arial, Helvetica, sans-serif;
  --font-body: Arial, Helvetica, sans-serif;
  --font-mono: Arial, Helvetica, sans-serif;

  --radius: 18px;
  --max-w: 1180px;
}

*, *::before, *::after{ box-sizing: border-box; }
html{ scroll-behavior: smooth; font-size: 20px; }

body{
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: var(--font-body);
  font-weight: 500;
  font-size: 1.05rem;
  line-height: 1.65;
  -webkit-font-smoothing: antialiased;
}

a{ color: inherit; }
img, svg{ display: block; max-width: 100%; }

.wrap{
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 0 32px;
}

.eyebrow{
  font-family: var(--font-mono);
  font-size: 19.2px;
  letter-spacing: 0.1em;
  text-transform: uppercase;
  color: var(--teal-deep);
  font-weight: 700;
}

h1, h2, h3{
  font-family: var(--font-display);
  font-weight: 700;
  margin: 0;
  color: var(--ink);
}

h1{ font-size: clamp(2.1rem, 3.7vw, 3rem); line-height: 1.1; letter-spacing: -0.01em; }
h2{ font-size: clamp(1.8rem, 3vw, 2.5rem); line-height: 1.18; }
h3{ font-size: 1.35rem; }

p{ color: var(--ink-soft); margin: 0; font-weight: 500; }
.lede{ color: var(--ink); font-size: 1.2rem; }

/* ==========================================================================
   Nav
   ========================================================================== */

header.site-nav{
  position: sticky;
  top: 0;
  z-index: 40;
  background: rgba(245, 250, 248, 0.88);
  backdrop-filter: blur(10px);
  border-bottom: 1px solid var(--line);
}

.nav-row{
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 8px 32px;
  max-width: var(--max-w);
  margin: 0 auto;
}

.logo{
  display: flex;
  align-items: center;
  gap: 12px;
  font-family: var(--font-display);
  font-weight: 700;
  font-size: 3rem;
  color: var(--ink);
  text-decoration: none;
}
.logo .mark{
  width: 40px; height: 40px;
  display: inline-block;
}

nav.links{
  display: flex;
  gap: 26px;
  align-items: center;
  font-family: var(--font-mono);
  font-size: 18px;
  font-weight: 600;
  letter-spacing: 0.02em;
}
nav.links a{
  text-decoration: none;
  color: var(--ink-soft);
  padding-bottom: 4px;
  border-bottom: 1px solid transparent;
  transition: color .2s ease, border-color .2s ease;
}
nav.links a:not(.contact-btn){
  font-size: 24px;
}
nav.links a:hover,
nav.links a:focus-visible,
nav.links a.active{
  color: var(--teal-deep);
  border-color: var(--teal);
}
nav.links a.contact-btn{
  color: #fff;
  background: var(--coral);
  border: none;
  border-radius: 999px;
  padding: 8px 18px;
  display: inline-flex;
  align-items: center;
  gap: 8px;
}
nav.links a.contact-btn:hover, nav.links a.contact-btn:focus-visible{
  background: var(--coral-deep);
}

/* ==========================================================================
   Buttons
   ========================================================================== */

.btn{
  display: inline-flex;
  align-items: center;
  gap: 10px;
  font-family: var(--font-mono);
  font-size: 15px;
  font-weight: 700;
  letter-spacing: 0.02em;
  text-decoration: none;
  padding: 13px 24px;
  border-radius: 999px;
  border: 1px solid var(--teal);
  color: #fff;
  background: var(--teal);
  cursor: pointer;
  transition: transform .15s ease, box-shadow .2s ease, background .2s ease;
}
.hero-actions .btn,
.cta-band .btn{
  font-size: 18px;
  padding: 18px 32px;
}
.btn:hover, .btn:focus-visible{
  background: var(--teal-deep);
  border-color: var(--teal-deep);
  box-shadow: 0 6px 20px rgba(14,156,143,0.25);
}
.btn.ghost{
  background: transparent;
  color: var(--ink);
  border-color: var(--line);
}
.btn.ghost:hover, .btn.ghost:focus-visible{
  border-color: var(--teal);
  color: var(--teal-deep);
  background: transparent;
  box-shadow: none;
}
.btn.coral{
  background: var(--coral);
  border-color: var(--coral);
}
.btn.coral:hover, .btn.coral:focus-visible{
  background: var(--coral-deep);
  border-color: var(--coral-deep);
  box-shadow: 0 6px 20px rgba(255,107,74,0.3);
}
.btn:disabled{
  opacity: .5;
  cursor: default;
  box-shadow: none;
}

/* ==========================================================================
   Hero
   ========================================================================== */

.hero{
  padding: 88px 0 68px;
  display: grid;
  grid-template-columns: 1.05fr 0.95fr;
  gap: 48px;
  align-items: center;
}

.hero > .tagline{
  grid-column: 1 / -1;
  font-family: var(--font-display);
  font-weight: 600;
  font-size: clamp(1.05rem, 5.5vw, 3rem);
  line-height: 1.2;
  color: var(--coral);
  margin: 0 0 12px;
}
.tagline-sub{
  color: var(--ink-soft);
  font-weight: 500;
}
.hero-copy h1{ margin-bottom: 20px; }
.hero-actions{ display: flex; gap: 16px; align-items: center; flex-wrap: wrap; }

.hero-figure{
  position: relative;
  aspect-ratio: 1 / 1;
  border-radius: var(--radius);
  background: radial-gradient(circle at 30% 20%, rgba(14,156,143,0.10), transparent 60%), var(--surface);
  border: 1px solid var(--line);
  overflow: hidden;
}
#helix-svg{ width: 100%; height: 100%; }
.helix-strand{ fill: none; stroke-width: 3; }
.helix-strand.a{ stroke: var(--teal); }
.helix-strand.b{ stroke: var(--coral); }
.helix-rung{ stroke: var(--line); stroke-width: 2; }
.helix-node{ fill: var(--surface); stroke-width: 2.5; }
.helix-node.a{ stroke: var(--teal); }
.helix-node.b{ stroke: var(--coral); }

@keyframes drift{
  from{ transform: translateY(0); }
  to{ transform: translateY(-150px); }
}
.helix-group{
  animation: drift 9s linear infinite;
}

/* mRNA / siRNA binding figure */
.mrna-figure{
  position: relative;
  border-radius: var(--radius);
  background: radial-gradient(circle at 30% 20%, rgba(14,156,143,0.10), transparent 60%), var(--surface);
  border: 1px solid var(--line);
  overflow: hidden;
  padding: 10px 0;
  margin-top: 40px;
}
#mrna-svg{ width: 100%; height: auto; display: block; }
.mrna-group{ animation: settle-in .8s ease both; }

.mrna-strand{ fill: none; stroke: var(--teal); stroke-width: 3; stroke-linecap: round; }
.mrna-node{ fill: var(--surface); stroke: var(--teal); stroke-width: 2.5; }

.sirna-strand{ fill: none; stroke: var(--coral); stroke-width: 3; stroke-linecap: round; }
.sirna-node{ fill: var(--surface); stroke: var(--coral); stroke-width: 2.5; }
.sirna-rung{ stroke: var(--line); stroke-width: 1.5; }

.binding-glow{ fill: var(--coral); }

/* one shared loop: mRNA binds the siRNA, then cleaves in two and drifts
   away, then resets and repeats */
.mrna-half, .sirna-group, .binding-glow{
  transform-box: fill-box;
  transform-origin: center;
}
.mrna-half-left{ animation: cut-left 7s ease-in-out infinite; }
.mrna-half-right{ animation: cut-right 7s ease-in-out infinite; }
.sirna-group{ animation: cut-release 7s ease-in-out infinite; }
.binding-glow{ animation: cut-glow 7s ease-in-out infinite; }

@keyframes cut-left{
  0%, 45%{ transform: translate(0, 0) rotate(0deg); opacity: 1; }
  68%, 92%{ transform: translate(-34px, 44px) rotate(-9deg); opacity: 0; }
  100%{ transform: translate(0, 0) rotate(0deg); opacity: 1; }
}
@keyframes cut-right{
  0%, 45%{ transform: translate(0, 0) rotate(0deg); opacity: 1; }
  68%, 92%{ transform: translate(34px, 44px) rotate(9deg); opacity: 0; }
  100%{ transform: translate(0, 0) rotate(0deg); opacity: 1; }
}
@keyframes cut-release{
  0%, 40%{ transform: translateY(0); opacity: 1; }
  58%, 92%{ transform: translateY(-16px); opacity: 0; }
  100%{ transform: translateY(0); opacity: 1; }
}
@keyframes cut-glow{
  0%, 40%{ opacity: 0.22; }
  58%, 95%{ opacity: 0; }
  100%{ opacity: 0.22; }
}

@media (prefers-reduced-motion: reduce){
  .mrna-group{ animation: none; }
  .mrna-half, .sirna-group{ animation: none; opacity: 1; transform: none; }
  .binding-glow{ animation: none; opacity: 0.18; }
}

/* ==========================================================================
   Sections
   ========================================================================== */

section{ padding: 60px 0; }
section.divider-top{ border-top: 1px solid var(--line); }
section.roster-section{ padding-top: 96px; }

.section-head{
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 24px;
  margin-bottom: 38px;
  flex-wrap: wrap;
}
.section-head p{ max-width: 64ch; }

.grid-2{
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 22px;
}

.patient-story{
  margin: 20px 0 0;
  padding: 32px 36px;
  border-radius: var(--radius);
  background: var(--surface);
}
.patient-story p{
  color: var(--ink);
  font-size: 1.15rem;
  max-width: 70ch;
}
.patient-story .patient-quote{
  margin-top: 16px;
  font-family: var(--font-display);
  font-weight: 700;
  font-size: 1.6rem;
  color: var(--coral-deep);
}

.facts-grid{
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 22px;
}
.fact-card{
  text-align: center;
  padding: 30px 22px;
  border: 1px solid var(--line);
  border-radius: var(--radius);
  background: var(--surface);
}
.fact-num{
  display: block;
  font-family: var(--font-display);
  font-weight: 700;
  font-size: 2.1rem;
  color: var(--coral);
  margin-bottom: 12px;
}
.fact-label{
  font-size: 1rem;
  font-weight: 600;
  color: var(--ink-soft);
  line-height: 1.45;
}
.fact-label strong{ color: var(--ink); }

.card{
  background: var(--surface);
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 28px;
}
.card .index{
  font-family: var(--font-mono);
  font-size: 14px;
  font-weight: 700;
  color: var(--ink-faint);
  letter-spacing: .1em;
  display: block;
  margin-bottom: 16px;
}
.card h3{ margin-bottom: 12px; }
.card p{ font-size: 1.05rem; }

.cta-band{
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 46px;
  display: flex;
  justify-content: space-between;
  align-items: center;
  gap: 24px;
  background: linear-gradient(135deg, var(--teal-tint), transparent 65%);
  flex-wrap: wrap;
}

/* ==========================================================================
   Footer
   ========================================================================== */

footer{
  border-top: 1px solid var(--line);
  padding: 36px 0 52px;
  margin-top: 24px;
}
.footer-row{
  display: flex;
  justify-content: space-between;
  align-items: center;
  flex-wrap: wrap;
  gap: 16px;
}
footer .fine{
  font-family: var(--font-mono);
  font-size: 14px;
  font-weight: 600;
  color: var(--ink-faint);
}

/* ==========================================================================
   About — intro
   ========================================================================== */

.about-intro{
  padding-top: 68px;
  padding-bottom: 48px;
}
.about-intro h1{ margin-bottom: 20px; }
.about-intro p.lede{ max-width: 72ch; }

/* ==========================================================================
   Brain diagram
   ========================================================================== */

.brain-section{
  display: grid;
  grid-template-columns: 1.05fr 0.95fr;
  gap: 40px;
  align-items: start;
}

.brain-stage{
  position: relative;
  background: var(--surface);
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 24px;
}
.brain-stage .hint{
  font-family: var(--font-mono);
  font-size: 13px;
  font-weight: 600;
  color: var(--ink-faint);
  text-align: center;
  margin-top: 10px;
  letter-spacing: .05em;
}

#brain-svg{ width: 100%; height: auto; overflow: visible; }

.brain-illustration{
  opacity: 0.88;
}

/* gentle idle animation on the whole illustration + its pins */
@keyframes breathe{
  0%, 100%{ transform: scale(1); }
  50%{ transform: scale(1.012); }
}
@keyframes settle-in{
  from{ opacity: 0; transform: scale(0.94) translateY(10px); }
  to{ opacity: 1; transform: scale(1) translateY(0); }
}
.brain-group{
  animation: breathe 6s ease-in-out infinite, settle-in .8s ease both;
  transform-box: fill-box;
  transform-origin: center;
}
@media (prefers-reduced-motion: reduce){
  .brain-group{ animation: none; }
}

/* -------- coordinate pin markers -------- */

.marker{ cursor: pointer; }

.marker .ping{
  fill: none;
  stroke: currentColor;
  stroke-width: 2.5;
  opacity: 0;
  transform-box: fill-box;
  transform-origin: center;
  animation: ping 3.4s ease-out infinite;
  pointer-events: none;
}
@keyframes ping{
  0%{ transform: scale(0.4); opacity: 0.55; }
  70%{ transform: scale(1.9); opacity: 0; }
  100%{ transform: scale(1.9); opacity: 0; }
}
@media (prefers-reduced-motion: reduce){
  .marker .ping{ animation: none; opacity: 0; }
}

.marker .halo{
  fill: currentColor;
  opacity: 0.16;
  transition: opacity .2s ease, r .2s ease;
}
.marker .dot{
  fill: currentColor;
  stroke: var(--surface);
  stroke-width: 3;
  transition: r .2s ease, filter .2s ease;
}
.marker .tag{
  font-family: var(--font-mono);
  font-size: 15px;
  letter-spacing: .02em;
  fill: var(--ink);
  opacity: 0;
  transition: opacity .18s ease;
  pointer-events: none;
}
.marker .tag-bg{
  fill: var(--surface);
  stroke: var(--line);
  stroke-width: 1;
  opacity: 0;
  transition: opacity .18s ease;
  pointer-events: none;
}
.marker:hover .dot, .marker:focus-visible .dot, .marker.active .dot{
  r: 13;
  filter: drop-shadow(0 0 10px currentColor);
}
.marker:hover .halo, .marker:focus-visible .halo, .marker.active .halo{
  opacity: 0.32;
  r: 34;
}
.marker:hover .tag, .marker:focus-visible .tag,
.marker:hover .tag-bg, .marker:focus-visible .tag-bg,
.marker.active .tag, .marker.active .tag-bg{
  opacity: 1;
}
.marker:focus-visible .dot{ outline: none; }

/* detail panel */
.detail-panel{
  background: var(--surface);
  border: 1px solid var(--line);
  border-radius: var(--radius);
  padding: 30px;
  min-height: 380px;
  display: flex;
  flex-direction: column;
  gap: 18px;
  position: sticky;
  top: 92px;
}

.detail-empty{
  margin: auto;
  text-align: center;
  color: var(--ink-faint);
  font-family: var(--font-mono);
  font-size: 13px;
  max-width: 30ch;
}

.detail-header{
  display: flex;
  align-items: center;
  gap: 16px;
}
.avatar{
  width: 60px; height: 60px;
  border-radius: 50%;
  overflow: hidden;
  border: 2px solid var(--line);
  flex-shrink: 0;
  background: var(--surface-dim);
}
.avatar img{ width: 100%; height: 100%; object-fit: cover; }

.detail-name{ font-family: var(--font-display); font-weight: 700; font-size: 1.35rem; color: var(--ink); }
.detail-title{ font-family: var(--font-mono); font-size: 14px; font-weight: 700; color: var(--teal-deep); text-transform: uppercase; letter-spacing: .05em; margin-top: 4px; }

.detail-bio{ color: var(--ink-soft); font-size: 1.05rem; font-weight: 500; }

.detail-founded{
  margin: 0;
  padding-left: 20px;
  display: flex;
  flex-direction: column;
  gap: 8px;
}
.detail-founded li{
  color: var(--ink-soft);
  font-size: 1.05rem;
  font-weight: 500;
}

.detail-links{
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.detail-link{
  display: inline-flex;
  align-items: center;
  gap: 6px;
  font-family: var(--font-mono);
  font-size: 18px;
  font-weight: 700;
  color: var(--teal-deep);
  text-decoration: none;
  width: fit-content;
}
.detail-link:hover, .detail-link:focus-visible{ text-decoration: underline; }

.detail-affiliations{
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 20px;
  padding-top: 18px;
  border-top: 1px solid var(--line);
}
.affiliation-logo{
  height: 22px;
  width: auto;
  max-width: 100px;
  object-fit: contain;
  opacity: 0.85;
  filter: grayscale(1);
  transition: opacity .2s ease, filter .2s ease;
}
.affiliation-logo:hover{
  opacity: 1;
  filter: grayscale(0);
}

.home-affiliations{
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  justify-content: space-between;
  gap: 40px;
  margin-top: 20px;
  width: 100%;
}
.affiliation-logo-lg{
  height: 60px;
  width: auto;
  max-width: 340px;
  object-fit: contain;
  opacity: 0.85;
  filter: grayscale(1);
  transition: opacity .2s ease, filter .2s ease;
}
.affiliation-logo-lg:hover{
  opacity: 1;
  filter: grayscale(0);
}

.linkedin-link{
  margin-left: auto;
  flex-shrink: 0;
  width: 34px; height: 34px;
  border-radius: 50%;
  display: flex;
  align-items: center;
  justify-content: center;
  color: var(--ink-faint);
  background: var(--surface-dim);
  border: 1px solid var(--line);
  transition: color .2s ease, border-color .2s ease, background .2s ease;
}
.linkedin-link:hover, .linkedin-link:focus-visible{
  color: #fff;
  background: #0A66C2;
  border-color: #0A66C2;
  outline: none;
}

/* roster */
.roster{
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 20px;
  margin-top: 20px;
}
.roster-card{
  display: flex;
  gap: 14px;
  align-items: center;
  padding: 16px;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: var(--surface);
  cursor: pointer;
  text-align: left;
  transition: border-color .2s ease, transform .2s ease;
}
.roster-card:hover, .roster-card:focus-visible, .roster-card.active-card{ border-color: var(--teal); outline: none; transform: translateY(-2px); }
.roster-card .avatar{ width: 46px; height: 46px; }
.roster-info{ min-width: 0; flex: 1; }
.roster-name{ font-size: 1.05rem; color: var(--ink); font-weight: 700; }
.roster-role{ font-family: var(--font-mono); font-size: 13px; font-weight: 600; color: var(--ink-faint); text-transform: uppercase; margin-top: 2px; }
.roster-card .linkedin-link{ width: 30px; height: 30px; }

/* ==========================================================================
   Responsive
   ========================================================================== */

@media (max-width: 900px){
  .hero, .brain-section{ grid-template-columns: 1fr; }
  .roster, .facts-grid{ grid-template-columns: 1fr 1fr; }
  .detail-panel{ position: static; }
}
@media (max-width: 620px){
  .grid-2, .roster, .facts-grid{ grid-template-columns: 1fr; }
  .nav-row{ padding: 14px 20px; }
  .wrap{ padding: 0 20px; }
  .cta-band{ flex-direction: column; align-items: flex-start; }
}

@media (max-width: 480px){
  .nav-row{ flex-wrap: wrap; gap: 10px 16px; row-gap: 10px; }
  .logo{ font-size: 1.05rem; }
  nav.links{ gap: 16px; font-size: 12px; flex-wrap: wrap; }
  nav.links a.contact-btn{ padding: 7px 14px; white-space: nowrap; }
}

@media (prefers-reduced-motion: reduce){
  *{ animation: none !important; transition: none !important; }
}